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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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|---|---|---|---|---|
| IAQELRRIGDEF | Palmitic acid |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd00010 | Peptide information |
| Sequence (one letter) | IAQELRRIGDEF |
| Length | 12 |
| Peptide name | Bim-BH3 domain core region |
| External ID | |
|---|---|
| CAS number | 2096257-89-3 |
| Other information | |
|---|---|
| Application | Type 2 diabetes mellitus therapy, protein tyrosine phosphatase 1B (PTP1B) inhibition, improves the insulin resistance effect in the insulin-resistant HepG2 cell model |
| Additional function | Possible anticancer therapy |
| Pharmacological class | other |
| Linker | N/A |
| Small molecule | Palmitic acid |
| Small molecule CAS | 57-10-3 |
| Small molecule structure | |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
BH3 mimetics derived from Bim-BH3 domain core region show PTP1B inhibitory activity. | 2019 | Lu, Xiao; Wu, Lijuan; Liu, Xiaochun; Wang, Shulin; Zhang, Chuanliang | Bioorganic and Medicinal Chemistry Letters | ||
