A DOTA-peptide conjugate by copper-free click chemistry

Authors: Martin, Molly E.; Parameswarappa, Sharavathi G.; O'Dorisio, M. Sue; Pigge, F. Christopher; Schultz, Michael K.; Bioorganic & Medicinal Chemistry; (2010); 10.1016/j.bmcl.2010.06.111

Attachment of DOTA to a novel monofluoro-cyclooctyne facilitates bioconjugation to an azide-modified peptide via Cu-free click chemistry. The resulting conjugate was radiolabeled with (111)In to afford a potential targeted molecular imaging agent with high specific activity and an excellent radiochemical purity.