Novel β-carboline-tripeptide conjugates attenuate mesenteric ischemia/reperfusion injury in the rat

Authors: Bi, Wei; Bi, Yue; Xue, Ping; Zhang, Yanrong; Gao, Xiang; Wang, Zhibo; Li, Meng; Baudy-Floc'h, Michele; Ngerebara, Nathaniel; Li, Xiaoxu; Gibson, K. Michael; Bi, Lanrong; European Journal of Medicinal Chemistry; (2011); 10.1016/j.ejmech.2011.03.029

We have synthesized a series of new ?-carboline-tripeptide conjugates, and examined their anti-inflammatory properties in a mouse model of xylene-induced ear edema. The analgesic capacity of these compounds was further evaluated in a rodent tail flick assay. Our results indicate that ?-carboline conjugate 4a manifests potent anti-inflammatory and analgesic activity while exerting a protective effect against mesenteric ischemia/reperfusion (I/R) injury in the rat.