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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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|---|---|---|---|---|
| QXRKXXXXKR | Chlorambucil |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd00362 |
| Smiles | |
| Inchi Key | InChIKey=SALWKRHUBCMOPF-SXOAGUHUSA-N |
| Molecular weight | 1599.79 |
| Molecular formula | C72H107Cl2N25O13 |
| Chemical name | Peptide information |
| Sequence (one letter) | QXRKXXXXKR |
| Length | 10 |
| Peptide name | high-affinity DNA binding peptide HyQ10 |
| External ID | |
|---|---|
| CAS number | 1616889-82-7 |
| Other information | |
|---|---|
| Application | Anticancer therapy |
| Additional function | DNA cleavage |
| Pharmacological class | anticancer |
| Conjugate type | amide |
| Linker | no |
| Small molecule | Chlorambucil |
| Small molecule CAS | 0305-03-03 |
| Calculated properties | |
|---|---|
| LogP | -3.56047 |
| Rotatable bonds | 47 |
| H bond donor | 18 |
| H bond acceptor | 22 |
| Polar surface area (PSA) | 592.42000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Enthalpy-driven nuclease-like activity and mechanism of peptide-chlorambucil conjugates | 2014 | Yang, Robin C. K.; Huang, Jonathan T. B.; Chen, Yu-Ling; Hung, Chia-Chun; Liao, Mokai; Yao, Wen-Chen; Chen, Chiu-Heng; Liou, Chien-Chung; Waring, Michael J.; Sheh, Leung | Organic & Biomolecular Chemistry | ||
