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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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| AACLRRIGDCVNLRQKLLN | 6,6′-Bis-bromomethyl-[3,3′]bipyridine |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd00361 |
| Smiles | |
| Inchi Key | InChIKey=TXGPCJWJQDURMW-YZENXEKJSA-N |
| Molecular weight | 2376.28 |
| Molecular formula | C104H173N35O25S2 |
| Chemical name | Peptide information |
| Sequence (one letter) | AACLRRIGDCVNLRQKLLN |
| Length | 19 |
| Peptide name | NoxaBH3 |
| External ID | |
|---|---|
| CAS number | 1541068-43-2 |
| Other information | |
|---|---|
| Application | Anticancer therapy, K562, U937, and Jurkat cells |
| Additional function | Targeting CXCR4 chemokine receptor |
| Pharmacological class | anticancer |
| Conjugate type | sulfide |
| Linker | no |
| Small molecule | 6,6′-Bis-bromomethyl-[3,3′]bipyridine |
| Small molecule CAS | 1334314-61-2 |
| Small molecule structure | |
| Calculated properties | |
|---|---|
| LogP | -13.28942 |
| Rotatable bonds | 60 |
| H bond donor | 31 |
| H bond acceptor | 37 |
| Polar surface area (PSA) | 1007.56000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Targeted Delivery of Ubiquitin-Conjugated BH3 Peptide-Based Mcl-1 Inhibitors into Cancer Cells | 2014 | Muppidi, Avinash; Doi, Kenichiro; Edwardraja, Selvakumar; Pulavarti, Surya V. S. R. K.; Szyperski, Thomas; Wang, Hong-Gang; Lin, Qing | Bioconjugate Chemistry | ||
