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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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 |
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|---|---|---|---|---|
| MXRKXXXXKR | Chlorambucil |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd00363 |
| Smiles | |
| Inchi Key | InChIKey=VHJPSBYFOYIVBG-KWYBGUKDSA-N |
| Molecular weight | 1602.77 |
| Molecular formula | C72H108Cl2N24O12S |
| Chemical name | Peptide information |
| Sequence (one letter) | MXRKXXXXKR |
| Length | 10 |
| Peptide name | high-affinity DNA binding peptide HyM10 |
| External ID | |
|---|---|
| CAS number | 1616889-81-6 |
| Other information | |
|---|---|
| Application | Anticancer therapy |
| Additional function | DNA cleavage |
| Pharmacological class | anticancer |
| Conjugate type | amide |
| Linker | no |
| Small molecule | Chlorambucil |
| Small molecule CAS | 0305-03-03 |
| Calculated properties | |
|---|---|
| LogP | -1.73765 |
| Rotatable bonds | 47 |
| H bond donor | 17 |
| H bond acceptor | 21 |
| Polar surface area (PSA) | 549.33000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Enthalpy-driven nuclease-like activity and mechanism of peptide-chlorambucil conjugates | 2014 | Yang, Robin C. K.; Huang, Jonathan T. B.; Chen, Yu-Ling; Hung, Chia-Chun; Liao, Mokai; Yao, Wen-Chen; Chen, Chiu-Heng; Liou, Chien-Chung; Waring, Michael J.; Sheh, Leung | Organic & Biomolecular Chemistry | ||
