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View Conjugates details

ConjuPepDB ID: cpd01103

Chemical structure


molecule
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cpd01103


Schematic Help Icon Schematic representation of peptide, linker and drug in the peptide-drug conjugates
VPVP 1-[(5R,6R,8R,9R)-4-amino-9-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2,2-dioxido-1,7-dioxa-2-thiaspiro[4.4]non-3-en-8-yl]-3-(3-aminopropyl)-5-methyl-2,4(1H,3H)-pyrimidinedione
Identification
ConjuPepDB ID

cpd01103

Smiles
Molecular weight

1172.57

Molecular formula

C55H88N8O14SSi2

Chemical name
Peptide information
Sequence (one letter)

VPVP

Length

4

Peptide name

tetrapeptide

External ID
CAS number

791112-08-8

Other information
Application

Antibiotic, antiviral (HIV)

Additional function

imporved relase and water solubility

Pharmacological class

antimicrobial, antiviral

Conjugate type

amide

Linker

no

Small molecule

1-[(5R,6R,8R,9R)-4-amino-9-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2,2-dioxido-1,7-dioxa-2-thiaspiro[4.4]non-3-en-8-yl]-3-(3-aminopropyl)-5-methyl-2,4(1H,3H)-pyrimidinedione

Small molecule CAS

672307-67-4

Structure method

1H NMR HPLC

Calculated properties
LogP

4.17410

Rotatable bonds

23

H bond donor

4

H bond acceptor

13

Polar surface area (PSA)

274.85000

Citations
ID Title Year Authors Journal DOI

cpdart0169

Efficient conversion of tetrapeptide-based TSAO prodrugs to the parent drug by dipeptidyl-peptidase IV (DPPIV/CD26)

2007

Garcia-Aparicio, Carlos; Diez-Torrubia, Alberto; Balzarini, Jan; Lambeir, Anne-Marie; Velazquez, Sonsoles; Camarasa, Maria-Jose

Antiviral Research

..