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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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| VAVP | 1-[(5R,6R,8R,9R)-4-amino-9-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2,2-dioxido-1,7-dioxa-2-thiaspiro[4.4]non-3-en-8-yl]-3-(3-aminopropyl)-5-methyl-2,4(1H,3H)-pyrimidinedione |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd01102 |
| Smiles | |
| Molecular weight | 1012.52 |
| Molecular formula | C45H80N8O12SSi2 |
| Chemical name | Peptide information |
| Sequence (one letter) | VAVP |
| Length | 4 |
| Peptide name | tetrapeptide |
| External ID | |
|---|---|
| CAS number | 791112-09-9 |
| Other information | |
|---|---|
| Application | Antibiotic, antiviral (HIV) |
| Additional function | imporved relase and water solubility |
| Pharmacological class | antimicrobial, antiviral |
| Conjugate type | amide |
| Linker | no |
| Small molecule | 1-[(5R,6R,8R,9R)-4-amino-9-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-6-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-2,2-dioxido-1,7-dioxa-2-thiaspiro[4.4]non-3-en-8-yl]-3-(3-aminopropyl)-5-methyl-2,4(1H,3H)-pyrimidinedione |
| Small molecule CAS | 672307-67-4 |
| Structure method | 1H NMR HPLC |
| Calculated properties | |
|---|---|
| LogP | 1.71600 |
| Rotatable bonds | 20 |
| H bond donor | 5 |
| H bond acceptor | 13 |
| Polar surface area (PSA) | 271.33000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Efficient conversion of tetrapeptide-based TSAO prodrugs to the parent drug by dipeptidyl-peptidase IV (DPPIV/CD26) | 2007 | Garcia-Aparicio, Carlos; Diez-Torrubia, Alberto; Balzarini, Jan; Lambeir, Anne-Marie; Velazquez, Sonsoles; Camarasa, Maria-Jose | Antiviral Research | ||
