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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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|---|---|---|---|---|
| HAIYPRHGGCGMPKKKPTPIQLNP | succinimide | doxorubicin |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd00009 |
| Smiles | |
| Inchi Key | InChIKey=YCKCTPSSGQKGJE-QFBZJQHYSA-N |
| Molecular weight | 3389.67 |
| Molecular formula | C155H232N40O42S2 |
| Chemical name | Peptide information |
| Sequence (one letter) | HAIYPRHGGCGMPKKKPTPIQLNP |
| Length | 24 |
| Peptide name | N/A |
| External ID | |
|---|---|
| CAS number | 2000174-85-4 |
| Other information | |
|---|---|
| Application | Anticancer therapy, breast cancer |
| Additional function | Dual-targeting, overcome drug resistance |
| Pharmacological class | anticancer |
| Conjugate type | sulfide |
| Linker | N/A |
| Linker Type | succinimide |
| Small molecule | doxorubicin |
| Small molecule CAS | 23214-92-8 |
| Small molecule structure | |
| Structure method | NMR |
| Calculated properties | |
|---|---|
| LogP | -16.83606 |
| Rotatable bonds | 94 |
| H bond donor | 38 |
| H bond acceptor | 53 |
| Polar surface area (PSA) | 1282.97000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Dual-targeting hybrid peptide-conjugated doxorubicin for drug resistance reversal in breast cancer. | 2016 | Sheng, Yuan; You, Yiwen; Chen, Yun | International Journal of Pharmaceutics | ||
