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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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|---|---|---|---|---|
| CRRRRRRRRGGGPKKKKKK | succinimide | doxorubicin |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd00008 |
| Smiles | |
| Inchi Key | InChIKey=YIWBEARCRSBMTC-YMPIMWEOSA-N |
| Molecular weight | 3100.72 |
| Molecular formula | C132H225N51O34S |
| Chemical name | Peptide information |
| Sequence (one letter) | CRRRRRRRRGGGPKKKKKK |
| Length | 19 |
| Peptide name | N/A |
| External ID | |
|---|---|
| CAS number | 1801419-50-0 |
| Other information | |
|---|---|
| Application | Anticancer therapy, HeLa and COS7 cells (prodrug) |
| Additional function | Improve cellular uptake |
| Pharmacological class | anticancer |
| Conjugate type | sulfide |
| Linker | N/A |
| Linker Type | succinimide |
| Small molecule | doxorubicin |
| Small molecule CAS | 23214-92-8 |
| Small molecule structure | |
| Structure method | NMR |
| Calculated properties | |
|---|---|
| LogP | -19.75526 |
| Rotatable bonds | 104 |
| H bond donor | 47 |
| H bond acceptor | 65 |
| Polar surface area (PSA) | 1496.18000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Activable Cell-Penetrating Peptide Conjugated Prodrug for Tumor Targeted Drug Delivery. | 2015 | Cheng, Hong; Zhu, Jing-Yi; Xu, Xiao-Ding; Qiu, Wen-Xiu; Lei, Qi; Han, Kai; Cheng, Yin-Jia; Zhang, Xian-Zheng | ACS Applied Materials & Interfaces | ||
