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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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 |
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|---|---|---|---|---|
| WRWRWRWRWK | glutaric acid | doxorubicin |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd00003 |
| Smiles | |
| Inchi Key | InChIKey=IDCWXFANIDKKMT-ROWWJEAZSA-N |
| Molecular weight | 2394.69 |
| Molecular formula | C120H148N0O24 |
| Chemical name | Peptide information |
| Sequence (one letter) | WRWRWRWRWK |
| Length | 10 |
| Peptide name | N/A |
| External ID | |
|---|---|
| CAS number | 1417821-48-7 |
| Other information | |
|---|---|
| Application | Anticancer therapy (prodrug) |
| Additional function | Targeting |
| Pharmacological class | anticancer |
| Conjugate type | amide |
| Linker | N/A |
| Linker Type | glutaric acid |
| Small molecule | doxorubicin |
| Small molecule CAS | 23214-92-8 |
| Small molecule structure | |
| Structure method | NMR |
| NMR solvent | DMSO-d6 |
| Calculated properties | |
|---|---|
| LogP | 0.13770 |
| Rotatable bonds | 45 |
| H bond donor | 34 |
| H bond acceptor | 36 |
| Polar surface area (PSA) | 887.89000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Design and biological evaluation of cell-penetrating peptide-doxorubicin conjugates as prodrugs. | 2013 | Nasrolahi Shirazi, Amir; Tiwari, Rakesh; Chhikara, Bhupender S; Mandal, Dindyal; Parang, Keykavous | Molecular pharmaceutics | ||
