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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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|---|---|---|---|---|
| MGLGLHLLVLAAALQGAKKKRKV | mercaptoacetic acid | Porfirin derivative |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd01526 |
| Smiles | |
| Molecular weight | 3290.88 |
| Molecular formula | C163H249N42O27S2 |
| Chemical name | Peptide information |
| Sequence (one letter) | MGLGLHLLVLAAALQGAKKKRKV |
| Length | 23 |
| Peptide name | amphipathic signal-nuclear localization peptide combination |
| External ID | |
|---|---|
| CAS number | 370100-95-1 |
| Other information | |
|---|---|
| Application | Anticancer therapy, DNA cleavage |
| Additional function | Improve cellular delivery and activity |
| Pharmacological class | anticancer |
| Conjugate type | amide |
| Linker | N/A |
| Linker Type | mercaptoacetic acid |
| Small molecule | Porfirin derivative |
| Small molecule CAS | 370100-96-2 |
| Structure method | HPLC |
| Calculated properties | |
|---|---|
| LogP | -13.42617 |
| Rotatable bonds | 102 |
| H bond donor | 36 |
| H bond acceptor | 37 |
| Polar surface area (PSA) | 1043.48000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Improvement of Porphyrin Cellular Delivery and Activity by Conjugation to a Carrier Peptide | 2001 | Chaloin, Laurent; Bigey, Pascal; Loup, Christophe; Marin, Mariana; Galeotti, Nathalie; Piechaczyk, Marc; Heitz, Frederic; Meunier, Bernard | Bioconjugate Chemistry | ||
