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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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|---|---|---|---|---|
| XRXXXXXR | hexanamide | 9-Acridinecarboxylic acid |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd01443 |
| Smiles | |
| Molecular weight | 1513.6 |
| Molecular formula | C70H79N23O17 |
| Chemical name | Peptide information |
| Sequence (one letter) | XRXXXXXR |
| Length | 8 |
| Peptide name | unnatural heptapeptide |
| External ID | |
|---|---|
| CAS number | 560071-14-9 |
| Other information | |
|---|---|
| Application | Synthesis |
| Additional function | Interacalators and DNA binding |
| Pharmacological class | other |
| Conjugate type | amide |
| Linker | N/A |
| Linker Type | hexanamide |
| Small molecule | 9-Acridinecarboxylic acid |
| Small molecule CAS | 5336-90-3 |
| Small molecule 2 | acid binding block? |
| Structure method | HPLC |
| Calculated properties | |
|---|---|
| LogP | -6.22687 |
| Rotatable bonds | 34 |
| H bond donor | 18 |
| H bond acceptor | 23 |
| Polar surface area (PSA) | 588.54000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
New dsDNA-binding hybrid molecules combining an unnatural peptide and an intercalating moiety | 2003 | Chaltin, Patrick; Borgions, Filip; Rozenski, Jef; Van Aerschot, Arthur; Herdewijn, Piet | Helvetica Chimica Acta | ||
