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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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| CGYGPKKKRKVGG | N-[2-[[12-[(6-chloro-2-methoxy-9-acridinyl)amino]-1-oxododecyl]amino]ethyl]-4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]-cyclohexanecarboxamide |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd01307 |
| Smiles | |
| Molecular weight | 2136.18 |
| Molecular formula | C103H162ClN25O20S |
| Chemical name | Peptide information |
| Sequence (one letter) | CGYGPKKKRKVGG |
| Length | 13 |
| Peptide name | N/A |
| External ID | |
|---|---|
| CAS number | 872979-88-9 |
| Other information | |
|---|---|
| Application | DNA binding |
| Additional function | Transport into the nucleus |
| Pharmacological class | other |
| Conjugate type | sulfide |
| Linker | no |
| Small molecule | N-[2-[[12-[(6-chloro-2-methoxy-9-acridinyl)amino]-1-oxododecyl]amino]ethyl]-4-[(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)methyl]-cyclohexanecarboxamide |
| Small molecule CAS | 872854-08-5 |
| Structure method | 1H and 13C NMR, HPLC |
| NMR solvent | CDCl3 |
| Calculated properties | |
|---|---|
| LogP | -2.99938 |
| Rotatable bonds | 73 |
| H bond donor | 24 |
| H bond acceptor | 30 |
| Polar surface area (PSA) | 719.67000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Synthesis of acridine-nuclear localization signal (NLS) conjugates and evaluation of their impact on lipoplex and polyplex-based transfection | 2005 | Boulanger, Caroline; Di Giorgio, Christophe; Vierling, Pierre | European Journal of Medicinal Chemistry | ||
