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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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 |
 |
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 |
|---|---|---|---|---|
| CRRMKWKK | maleimide | Paclitaxel |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd01294 |
| Smiles | |
| Molecular weight | 2138 |
| Molecular formula | C103H143N21O25S2 |
| Chemical name | Peptide information |
| Sequence (one letter) | CRRMKWKK |
| Length | 8 |
| Peptide name | Penetratin fragment |
| External ID | |
|---|---|
| CAS number | 888716-38-9 |
| Other information | |
|---|---|
| Application | Anticancer therapy, human lung and breast cancer cell lines |
| Additional function | Improving solubility an cell penetration |
| Pharmacological class | anticancer |
| Conjugate type | sulfide |
| Linker | N/A |
| Linker Type | maleimide |
| Small molecule | Paclitaxel |
| Small molecule CAS | 33069-62-4 |
| Structure method | 1H and 13C NMR, RP-HPLC |
| NMR solvent | CDCl5 |
| Calculated properties | |
|---|---|
| LogP | -1.87479 |
| Rotatable bonds | 62 |
| H bond donor | 22 |
| H bond acceptor | 30 |
| Polar surface area (PSA) | 755.20000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Synthesis and biological activity of conjugates between paclitaxel and the cell delivery vector penetratin | 2006 | Wang, Shudong; Zhelev, Nikolai Z.; Duff, Susan; Fischer, Peter M. | Bioorganic & Medicinal Chemistry | ||
