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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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|---|---|---|---|---|
| PID | Vinblastine |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd01058 |
| Smiles | |
| Molecular weight | 1342.66 |
| Molecular formula | C76H92N7O15 |
| Chemical name | Peptide information |
| Sequence (one letter) | PID |
| Length | 3 |
| Peptide name | tripeptide |
| External ID | |
|---|---|
| CAS number | 1097833-58-3 |
| Other information | |
|---|---|
| Application | Anticancer, antimitotic |
| Pharmacological class | anticancer |
| Conjugate type | amide |
| Linker | no |
| Small molecule | Vinblastine |
| Small molecule CAS | 865-21-4 |
| Small molecule structure | |
| Structure method | 1H and 13C NMR, COSY |
| NMR solvent | CDCl4 |
| Calculated properties | |
|---|---|
| LogP | 3.05795 |
| Rotatable bonds | 27 |
| H bond donor | 4 |
| H bond acceptor | 12 |
| Polar surface area (PSA) | 261.74000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Synthesis and Biological Evaluation of Vinca Alkaloids and Phomopsin Hybrids | 2009 | Ngo, Quoc Anh; Roussi, Fanny; Cormier, Anthony; Thoret, Sylviane; Knossow, Marcel; Guenard, Daniel; Gueritte, Francoise | Journal of Medicinal Chemistry | ||
