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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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|---|---|---|---|---|
| RGDS | succinic acid | Estradiol |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd01044 |
| Smiles | |
| Molecular weight | 1060.49 |
| Molecular formula | C56H68N8O13 |
| Chemical name | Peptide information |
| Sequence (one letter) | RGDS |
| Length | 4 |
| Peptide name | tetrapeptide |
| External ID | |
|---|---|
| CAS number | 946144-06-5 |
| Other information | |
|---|---|
| Application | Osteoporosis therapy |
| Additional function | enhance potency, reduce side effects and improve oral propert |
| Pharmacological class | other |
| Conjugate type | amide |
| Linker | N/A |
| Linker Type | succinic acid |
| Small molecule | Estradiol |
| Small molecule CAS | 50-28-2 |
| Small molecule structure | |
| Structure method | 1H and 13C NMR |
| NMR solvent | DMSO-d6 or CDCl3 |
| Calculated properties | |
|---|---|
| LogP | 4.35274 |
| Rotatable bonds | 28 |
| H bond donor | 8 |
| H bond acceptor | 14 |
| Polar surface area (PSA) | 298.74000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Synthesis, evaluation and 3D QSAR analysis of novel estradiol-RGD octapeptide conjugates with oral anti-osteoporosis activity | 2009 | Liu, Jiangyuan; Zhang, Xiaoyi; Zhao, Ming; Peng, Shiqi | European Journal of Medicinal | ||
