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View Conjugates details

ConjuPepDB ID: cpd01030

Chemical structure


molecule
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cpd01030


Schematic Help Icon Schematic representation of peptide, linker and drug in the peptide-drug conjugates
RGDS glycolic acid Estradiol
Identification
ConjuPepDB ID

cpd01030

Smiles
Molecular weight

787.375

Molecular formula

C37H53N7O12

Chemical name
Peptide information
Sequence (one letter)

RGDS

Length

4

Peptide name

tetrapeptide

External ID
CAS number

906673-86-7

Other information
Application

Osteoporosis therapy

Additional function

Increasing oral potency and decrassing side effect

Pharmacological class

other

Conjugate type

amide

Linker

N/A

Linker Type

glycolic acid

Small molecule

Estradiol

Small molecule CAS

50-28-2

Small molecule structure

Calculated properties
LogP

-3.19008

Rotatable bonds

20

H bond donor

11

H bond acceptor

14

Polar surface area (PSA)

319.66000

Citations
ID Title Year Authors Journal DOI

cpdart0152

3D QSAR of novel estrogen-RGD peptide conjugates: Getting insight into structural dependence of anti-osteoporosis activity and side effect of estrogen in ERT

2009

Zhao, Ming; Liu, Jiangyuan; Zhang, Xiaoyi; Peng, Li; Li, Chunyu; Peng, Shiqi

Bioorganic & Medicinal Chemistry

..