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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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|---|---|---|---|---|
| RGDS | glycolic acid | Estradiol |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd01027 |
| Smiles | |
| Molecular weight | 745.365 |
| Molecular formula | C35H51N7O11 |
| Chemical name | Peptide information |
| Sequence (one letter) | RGDS |
| Length | 4 |
| Peptide name | tetrapeptide |
| External ID | |
|---|---|
| CAS number | 906673-92-5 |
| Other information | |
|---|---|
| Application | Osteoporosis therapy |
| Additional function | Increasing oral potency and decrassing side effect |
| Pharmacological class | other |
| Conjugate type | amide |
| Linker | N/A |
| Linker Type | glycolic acid |
| Small molecule | Estradiol |
| Small molecule CAS | 50-28-2 |
| Small molecule structure | |
| Calculated properties | |
|---|---|
| LogP | -3.83219 |
| Rotatable bonds | 18 |
| H bond donor | 11 |
| H bond acceptor | 14 |
| Polar surface area (PSA) | 302.59000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
3D QSAR of novel estrogen-RGD peptide conjugates: Getting insight into structural dependence of anti-osteoporosis activity and side effect of estrogen in ERT | 2009 | Zhao, Ming; Liu, Jiangyuan; Zhang, Xiaoyi; Peng, Li; Li, Chunyu; Peng, Shiqi | Bioorganic & Medicinal Chemistry | ||
