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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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|---|---|---|---|---|
| RIKPHQGQHIGQFPQIM | PEG | meso-porphyrin derivative |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd00983 |
| Smiles | |
| Molecular weight | 2907.47 |
| Molecular formula | C148H194N36O25S |
| Chemical name | Peptide information |
| Sequence (one letter) | RIKPHQGQHIGQFPQIM |
| Length | 17 |
| Peptide name | N/A |
| External ID | |
|---|---|
| CAS number | 1190101-29-1 |
| Other information | |
|---|---|
| Application | Anticancer therapy, photosensitizing |
| Additional function | Targeting, VEGF-R2 and tumour neovasculature |
| Pharmacological class | anticancer |
| Conjugate type | amide |
| Linker | N/A |
| Linker Type | PEG |
| Small molecule | meso-porphyrin derivative |
| Small molecule CAS | 118230-31-2 |
| Structure method | 1H NMR, MALDI Mass spectrometry, absorption and fluorescence spectroscopies |
| Calculated properties | |
|---|---|
| LogP | 1.37834 |
| Rotatable bonds | 54 |
| H bond donor | 27 |
| H bond acceptor | 35 |
| Polar surface area (PSA) | 905.76000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
An efficient route to VEGF-like peptide porphyrin conjugates via microwave-assisted 'click-chemistry' | 2009 | Bakleh, M. E.; Sol, V.; Estieu-Gionnet, K.; Granet, R.; Deleris, G.; Krausz, P. | Tetrahedron | ||
