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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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|---|---|---|---|---|
| PQPSKSA | ADP ribose |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd00908 |
| Smiles | |
| Inchi Key | InChIKey=QOICLPYDJZWUGQ-DAFITTSSSA-N |
| Molecular weight | 1295.46 |
| Molecular formula | C47H75N15O24P2 |
| Chemical name | Peptide information |
| Sequence (one letter) | PQPSKSA |
| Length | 7 |
| Peptide name | oligopeptide |
| External ID | |
|---|---|
| CAS number | 1220340-48-6 |
| Other information | |
|---|---|
| Application | Synthesis |
| Additional function | Protected ribosylated asparagine and glutamine building blocks suitable for Fmoc-based peptide synthesis |
| Conjugate type | amide |
| Linker | no |
| Small molecule | ADP ribose |
| Small molecule CAS | 20762-30-5 |
| Small molecule structure | |
| Structure method | 31P- and NOESY-NMR |
| Calculated properties | |
|---|---|
| LogP | -13.64092 |
| Rotatable bonds | 31 |
| H bond donor | 17 |
| H bond acceptor | 26 |
| Polar surface area (PSA) | 596.08000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Synthesis of Mono-ADP-Ribosylated Oligopeptides Using Ribosylated Amino Acid Building Blocks | 2010 | van der Heden van Noort, Gerbrand J.; van der Horst, Maarten G.; Overkleeft, Herman S.; van der Marel, Gijsbert A.; Filippov, Dmitri V. | Journal of the American Chemical Society | ||
