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ConjuPepDB ID: cpd00783

Chemical structure


molecule
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cpd00783


Schematic Help Icon Schematic representation of peptide, linker and drug in the peptide-drug conjugates
RPAK p-Toluenesulfonamide
Identification
ConjuPepDB ID

cpd00783

Smiles
Molecular weight

948.442

Molecular formula

C47H64N8O11S

Chemical name
Peptide information
Sequence (one letter)

RPAK

Length

4

Peptide name

pentapeptide generated by plasmin degradation from the fibrinogen beta chain

External ID
CAS number

202411-01-6

Other information
Application

Anti-thrombolytic therapy

Additional function

Free radical scavenging and thrombolitic activity, protective effect against organ injury induced by I/R in rat

Conjugate type

sulfonamide

Linker

no

Small molecule

p-Toluenesulfonamide

Small molecule CAS

70-55-3

Small molecule structure

NMR solvent

CD3OD + TFA

Calculated properties
LogP

4.62176

Rotatable bonds

25

H bond donor

7

H bond acceptor

10

Polar surface area (PSA)

263.52000

Citations
ID Title Year Authors Journal DOI

Cpdart0119

A new class of β-carboline alkaloid-peptide conjugates with therapeutic efficacy in acute limb ischemia/reperfusion injury

2011

Bi, Wei; Bi, Yue; Xue, Ping; Zhang, Yanrong; Gao, Xiang; Wang, Zhibo; Li, Meng; Baudy-Floc'h, Michele; Ngerebara, Nathaniel; Michael Gibson, K.; Bi, Lanrong

European Journal of Medicinal Chemistry

..