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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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|---|---|---|---|---|
| CMYIEALDKYAC | glutaric acid | Doxorubicin |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd00718 |
| Smiles | |
| Inchi Key | InChIKey=NXOWGOSFXJOUOC-BXGBUJIHSA-N |
| Molecular weight | 2060.8 |
| Molecular formula | C94H128N14O32S3 |
| Chemical name | Peptide information |
| Sequence (one letter) | CMYIEALDKYAC |
| Length | 12 |
| Peptide name | EGFR-binding peptide (EBP) |
| External ID | |
|---|---|
| CAS number | 1268633-55-1 |
| Other information | |
|---|---|
| Application | Anticancer therapy, SW480, SGC-7901, MCF-7 |
| Additional function | Targeting EGFR overexpressing tumor cells, enhance efficacy and reduce systemic toxicity |
| Conjugate type | amide |
| Linker | N/A |
| Linker Type | glutaric acid |
| Small molecule | Doxorubicin |
| Small molecule CAS | 23214-92-8 |
| Small molecule structure | |
| Structure method | NMR |
| Calculated properties | |
|---|---|
| LogP | -4.15190 |
| Rotatable bonds | 57 |
| H bond donor | 25 |
| H bond acceptor | 33 |
| Polar surface area (PSA) | 739.72000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Biological Evaluation of a Novel Doxorubicin-Peptide Conjugate for Targeted Delivery to EGF Receptor-Overexpressing Tumor Cells | 2011 | Ai, Shibin; Duan, Jianli; Liu, Xin; Bock, Stephanie; Tian, Yuan; Huang, Zebo | Molecular Pharmaceutics | ||
