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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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| YVLWKRKRKFCFI | succinimide | Protoporphyrin IX derivative |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd00662 |
| Smiles | |
| Inchi Key | InChIKey=VPJCWLASXALFBA-GRHUZDHQSA-N |
| Molecular weight | 2469.34 |
| Molecular formula | C128H176N30O19S |
| Chemical name | Peptide information |
| Sequence (one letter) | YVLWKRKRKFCFI |
| Length | 13 |
| Peptide name | lipopolysaccharide (LPS) binding antimicrobial peptide YI13WF |
| External ID | |
|---|---|
| CAS number | 1385013-74-0 |
| Other information | |
|---|---|
| Application | Antimicrobial therapy, antibacterial, photosensitizer (Gram-negative) |
| Additional function | Targeting LPS binding antimicrobial peptide, fluorescent imaging |
| Conjugate type | sulfide |
| Linker | N/A |
| Linker Type | succinimide |
| Small molecule | Protoporphyrin IX derivative |
| Small molecule CAS | 0553-12-8 |
| Structure method | 1H-NMR |
| Calculated properties | |
|---|---|
| LogP | 2.91989 |
| Rotatable bonds | 72 |
| H bond donor | 27 |
| H bond acceptor | 31 |
| Polar surface area (PSA) | 822.33000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Lipopolysaccharide Neutralizing Peptide-Porphyrin Conjugates for Effective Photoinactivation and Intracellular Imaging of Gram-Negative Bacteria Strains | 2012 | Liu, Fang; Soh Yan Ni, Annie; Lim, Yingjie; Mohanram, Harini; Bhattacharjya, S.; Xing, Bengang | Bioconjugate Chemistry | ||
