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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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|---|---|---|---|---|
| DGGDGGDGGDGPLGLAGRRRRRRRRRC | succinimide | Doxorubicin |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd00635 |
| Smiles | |
| Inchi Key | InChIKey=UXRTWRPPKHIODT-PEENLXOHSA-N |
| Molecular weight | 3587.69 |
| Molecular formula | C145H230N56O50S |
| Chemical name | Peptide information |
| Sequence (one letter) | DGGDGGDGGDGPLGLAGRRRRRRRRRC |
| Length | 27 |
| Peptide name | activable cell-penetrating peptide (ACCP) |
| External ID | |
|---|---|
| CAS number | 1427354-59-3 |
| Other information | |
|---|---|
| Application | Anticancer therapy |
| Additional function | Targeting matrix metalloproteinase-2 and -9 (MMP-2/9) |
| Conjugate type | sulfide |
| Linker | N/A |
| Linker Type | succinimide |
| Small molecule | Doxorubicin |
| Small molecule CAS | 23214-92-8 |
| Small molecule structure | |
| Structure method | 1H-NMR |
| NMR solvent | DMSO-d6 |
| Calculated properties | |
|---|---|
| LogP | -27.52999 |
| Rotatable bonds | 112 |
| H bond donor | 58 |
| H bond acceptor | 78 |
| Polar surface area (PSA) | 1778.96000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Enhancing cellular uptake of activable cell-penetrating peptide-doxorubicin conjugate by enzymatic cleavage | 2012 | Shi, Nian-Qiu; Gao, Wei; Xiang, Bai; Qi, Xian-Rong | International Journal of Nanomedicine | ||
