3D model is for representation purpose only.
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CYGRKKRRQRRR | 2,2′-Dithiobis[5-nitropyridine] |
Identification | |
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ConjuPepDB ID | cpd00540 |
Smiles | |
Inchi Key | InChIKey=YVKFISDBNIVUNR-RZGVDQIZSA-N |
Molecular weight | 1814.96 |
Molecular formula | C72H126N36O16S2 |
Chemical name | Peptide information |
Sequence (one letter) | CYGRKKRRQRRR |
Length | 12 |
Peptide name | TAT (fragment) |
External ID | |
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CAS number | 1433417-38-9 |
Other information | |
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Application | Anticancer therapy, PKC inhibition |
Additional function | Possible strategy for selective, cell-penetrating kinase inhibitor against cancer, immunological disorders, and neurodegenerative diseases |
Pharmacological class | anticancer |
Conjugate type | disulfide |
Linker | no |
Small molecule | 2,2′-Dithiobis[5-nitropyridine] |
Small molecule CAS | 2127-10-8 |
Small molecule structure | |
Calculated properties | |
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LogP | -12.21639 |
Rotatable bonds | 65 |
H bond donor | 29 |
H bond acceptor | 38 |
Polar surface area (PSA) | 949.68000 |
Citations | |||||
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ID | Title | Year | Authors | Journal | DOI |
Cell-Penetrating Bisubstrate-Based Protein Kinase C Inhibitors | 2013 | van Wandelen, Loek T. M.; van Ameijde, Jeroen; Ismail-Ali, Ahmed F.; van Ufford, H. C. Quarles; Vijftigschild, Lodewijk A. W.; Beekman, Jeffrey M.; Martin, Nathaniel I.; Ruijtenbeek, Rob; Liskamp, Rob M. J. | ACS Chemical Biology |