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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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|---|---|---|---|---|
| GRKKRRQRRRPPQK | 5-FAM (Hydroxyfluorescein) dye |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd00529 |
| Smiles | |
| Inchi Key | InChIKey=FTPOFNJKWZDMPC-OMUVQOCOSA-N |
| Molecular weight | 2245.22 |
| Molecular formula | C99H156N38O23 |
| Chemical name | Peptide information |
| Sequence (one letter) | GRKKRRQRRRPPQK |
| Length | 14 |
| Peptide name | TAT-analogue |
| External ID | |
|---|---|
| CAS number | 1427500-01-3 |
| Other information | |
|---|---|
| Application | Anticancer therapy, KB-3-1 and KB-V1 cells |
| Additional function | Improved cellular uptake and toxicity, overcome drug resistance |
| Pharmacological class | anticancer |
| Conjugate type | amide |
| Linker | no |
| Small molecule | 5-FAM (Hydroxyfluorescein) dye |
| Small molecule CAS | 76823-03-05 |
| Calculated properties | |
|---|---|
| LogP | -13.48580 |
| Rotatable bonds | 70 |
| H bond donor | 32 |
| H bond acceptor | 41 |
| Polar surface area (PSA) | 1062.62000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Cellular uptake and cytotoxicity of drug-peptide conjugates regulated by conjugation site | 2013 | Zhang, Pengcheng; Cheetham, Andrew G.; Lock, Lye Lin; Cui, Honggang | Bioconjugate Chemistry | ||
