3D model is for representation purpose only.
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GFLG | 3-Maleimidopropionic acid |
Identification | |
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ConjuPepDB ID | cpd00525 |
Smiles | |
Inchi Key | InChIKey=IQUCPPQTLGEQEK-OALUTQOASA-N |
Molecular weight | 543.233 |
Molecular formula | C26H33N5O8 |
Chemical name | Peptide information |
Sequence (one letter) | GFLG |
Length | 4 |
Peptide name | enzyme-cleavable peptidic linker |
External ID | |
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CAS number | 1427500-04-6 |
Other information | |
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Application | Anticancer therapy, KB-3-1 and KB-V1 cells |
Additional function | Improved cellular uptake and toxicity, overcome drug resistance |
Pharmacological class | anticancer |
Conjugate type | amide |
Linker | no |
Small molecule | 3-Maleimidopropionic acid |
Small molecule CAS | 7423-55-4 |
Small molecule structure | |
Calculated properties | |
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LogP | -1.07040 |
Rotatable bonds | 15 |
H bond donor | 5 |
H bond acceptor | 8 |
Polar surface area (PSA) | 191.08000 |
Citations | |||||
---|---|---|---|---|---|
ID | Title | Year | Authors | Journal | DOI |
Cellular uptake and cytotoxicity of drug-peptide conjugates regulated by conjugation site | 2013 | Zhang, Pengcheng; Cheetham, Andrew G.; Lock, Lye Lin; Cui, Honggang | Bioconjugate Chemistry |