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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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|---|---|---|---|---|
| VTPVSTA | butane | ‘linker-only’ uridine diphosphate (UDP) analogue |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd00439 |
| Smiles | |
| Inchi Key | InChIKey=QZUZNPLAFHMXLF-GIXKJQNGSA-N |
| Molecular weight | 1158.42 |
| Molecular formula | C43H72N10O23P2 |
| Chemical name | Peptide information |
| Sequence (one letter) | VTPVSTA |
| Length | 7 |
| Peptide name | O-GlcNAc transferase fragment |
| External ID | |
|---|---|
| CAS number | 1807977-98-5 |
| Other information | |
|---|---|
| Application | Synthesis, inhibition of glycosyltransfer (O-GlcNAc transferase) |
| Additional function | Possible tool for studying OGT function in vivo |
| Pharmacological class | other |
| Conjugate type | ether |
| Linker | N/A |
| Linker Type | butane |
| Small molecule | ‘linker-only’ uridine diphosphate (UDP) analogue |
| Small molecule CAS | 1807978-00-2 |
| Small molecule structure | |
| Calculated properties | |
|---|---|
| LogP | -7.09693 |
| Rotatable bonds | 30 |
| H bond donor | 14 |
| H bond acceptor | 20 |
| Polar surface area (PSA) | 489.08000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Bisubstrate UDP-peptide conjugates as human O-GlcNAc transferase inhibitors | 2014 | Borodkin, Vladimir S.; Schimpl, Marianne; Gundogdu, Mehmet; Rafie, Karim; Dorfmueller, Helge C.; Robinson, David A.; van Aalten, Daan M. F. | Biochemical Journal | ||
