conjupepdb_log

View Conjugates details

ConjuPepDB ID: cpd00383

Chemical structure


molecule
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cpd00383


Schematic Help Icon Schematic representation of peptide, linker and drug in the peptide-drug conjugates
TFFYGGSRGKRNNFKTEEY PEG 6-Maleimidocaproic acid derivative linker
Identification
ConjuPepDB ID

cpd00383

Smiles
Inchi Key

InChIKey=XOSUEDYGBJDGKL-ULEWEKNYSA-N

Molecular weight

3126.49

Molecular formula

C141H207N35O46

Chemical name
Peptide information
Sequence (one letter)

TFFYGGSRGKRNNFKTEEY

Length

19

Peptide name

DOTA10-AngioPep (DOTA-AP)

External ID
CAS number

1609258-60-7

Other information
Application

Synthesis, peptidic carrier to facilitate blood-brain barrier transport

Additional function

Diagnosis, in vivo PET imaging or combined PET/optical imaging of hD2 receptors

Pharmacological class

other

Conjugate type

amide

Linker

N/A

Linker Type

PEG

Small molecule

6-Maleimidocaproic acid derivative linker

Small molecule CAS

55750-53-3

Small molecule structure

Structure method

DMSO-d6

Calculated properties
LogP

-18.68711

Rotatable bonds

107

H bond donor

39

H bond acceptor

57

Polar surface area (PSA)

1264.31000

Citations
ID Title Year Authors Journal DOI

Cpdart0073

Shuttle-Cargo Fusion Molecules of Transport Peptides and the hD2/3 Receptor Antagonist Fallypride: A Feasible Approach To Preserve Ligand-Receptor Binding?

2014

Wangler, Carmen; Chowdhury, Shafinaz; Hofner, Georg; Djurova, Petia; Purisima, Enrico O.; Bartenstein, Peter; Wangler, Bjorn; Fricker, Gert; Wanner, Klaus T.; Schirrmacher, Ralf

Journal of Medicinal Chemistry

..