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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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| NXPKID | triazole | 1H-Thieno[3,4-d]imidazole-4-hexanamide, N-[2-[2-(azidomethoxy)ethoxy]ethyl]hexahydro-2-oxo-, (3aS,4S,6aR)- |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd00344 |
| Smiles | |
| Inchi Key | InChIKey=IWNJGIIERXBCSR-LOMRGWCDSA-N |
| Molecular weight | 1118.55 |
| Molecular formula | C49H78N14O14S |
| Chemical name | Peptide information |
| Sequence (one letter) | NXPKID |
| Length | 6 |
| Peptide name | hexapeptide |
| External ID | |
|---|---|
| CAS number | 1809332-28-2 |
| Other information | |
|---|---|
| Application | Synthesis, Y1-receptor binding |
| Additional function | Preparation of biotin and fluorophore-labelled peptides |
| Pharmacological class | other |
| Conjugate type | ether |
| Linker | N/A |
| Linker Type | triazole |
| Small molecule | 1H-Thieno[3,4-d]imidazole-4-hexanamide, N-[2-[2-(azidomethoxy)ethoxy]ethyl]hexahydro-2-oxo-, (3aS,4S,6aR)- |
| Small molecule CAS | 1809332-37-3 |
| Small molecule structure | |
| Calculated properties | |
|---|---|
| LogP | -6.45369 |
| Rotatable bonds | 27 |
| H bond donor | 10 |
| H bond acceptor | 17 |
| Polar surface area (PSA) | 392.06000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Propargyloxyproline regio- and stereoisomers for Click-conjugation of peptides: Synthesis and application in linear and cyclic peptides | 2015 | Northfield, Susan E.; Mountford, Simon J.; Wielens, Jerome; Liu, Mengjie; Zhang, Lei; Herzog, Herbert; Holliday, Nicholas D.; Scanlon, Martin J.; Parker, Michael W.; Chalmers, David K.; Thompson, Philip E. | Australian Journal of Chemistry | ||
