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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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| GDGVP | butyric acid | 3,4-Dihydro-4-oxo-2-quinazolinebutanoic acid |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd00105 |
| Smiles | |
| Inchi Key | InChIKey=XCALRGWNXOXEBJ-SVWFWBBMSA-N |
| Molecular weight | 823.354 |
| Molecular formula | C43H49N7O10 |
| Chemical name | Peptide information |
| Sequence (one letter) | GDGVP |
| Length | 5 |
| Peptide name | N/A |
| External ID | |
|---|---|
| CAS number | 2411424-04-7 |
| Other information | |
|---|---|
| Application | Antimicrobial therapy, antibacteraial (Gramm-positive and negative) |
| Additional function | Improve effect |
| Pharmacological class | antimicrobial, antibacterial |
| Conjugate type | amide |
| Linker | N/A |
| Linker Type | butyric acid |
| Small molecule | 3,4-Dihydro-4-oxo-2-quinazolinebutanoic acid |
| Small molecule CAS | 95494-51-2 |
| Small molecule structure | |
| Structure method | 1H- and 13C-NMR |
| Calculated properties | |
|---|---|
| LogP | 1.55487 |
| Rotatable bonds | 21 |
| H bond donor | 5 |
| H bond acceptor | 10 |
| Polar surface area (PSA) | 230.77000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Effect of low charge and high hydrophobicity on antimicrobial activity of the quinazolinone-peptide conjugates | 2018 | Rakesh, Kadallipura Puttaswamy; Ramesh, Suhas; Shivakumar; Gowda, Dase Channe | Russian Journal of Bioorganic Chemistry | ||
