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Schematic representation of peptide, linker and drug in the peptide-drug conjugates
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|---|---|---|---|---|
| XGSGANTPCGPYTHDCPVKR | mercaptoacetic acid | fluorescein isothiocyanate |
| Identification | |
|---|---|
| ConjuPepDB ID | cpd00020 |
| Smiles | |
| Inchi Key | InChIKey=FCEQMRXNWJITAF-PCQJVPFRSA-N |
| Molecular weight | 2460.01 |
| Molecular formula | C108H149N29O32S3 |
| Chemical name | Peptide information |
| Sequence (one letter) | XGSGANTPCGPYTHDCPVKR |
| Length | 20 |
| Peptide name | galectin-3 targeting peptide (G3-C12) |
| External ID | |
|---|---|
| CAS number | 1381795-65-8 |
| Other information | |
|---|---|
| Application | Chronic kidney disease (CKD) therapy, kidney targeted drug delivery |
| Pharmacological class | other |
| Conjugate type | amide |
| Linker | N/A |
| Linker Type | mercaptoacetic acid |
| Small molecule | fluorescein isothiocyanate |
| Small molecule CAS | 27072-45-3 |
| Small molecule structure | |
| Calculated properties | |
|---|---|
| LogP | -14.62161 |
| Rotatable bonds | 64 |
| H bond donor | 33 |
| H bond acceptor | 35 |
| Polar surface area (PSA) | 950.08000 |
| Citations | |||||
|---|---|---|---|---|---|
| ID | Title | Year | Authors | Journal | DOI |
Peptide-Drug Conjugate Linked via a Disulfide Bond for Kidney Targeted Drug Delivery | 2012 | Geng, Qian; Sun, Xun; Gong, Tao; Zhang, Zhi-Rong | Bioconjugate Chemistry | ||
